everolimus
Other Name: Afinitor®
For treating certain types of kidney and breast cancer, or other cancers which come from the pancreas, lung or stomach (neuroendocrine tumours).
- Tell your heatlh care team if you have or had significant medical condition(s) such as:
- lung, kidney, or liver problems (including hepatitis),
- diabetes,
- high cholesterol,
- active infection(s),
- upcoming surgery,
- or have any allergies.
- This drug contains a small amount of lactose. If you cannot tolerate lactose, talk to your doctor.
- People with cancer have a higher risk of getting other cancers or developing blood clots. Some cancer medications may increase these risks, especially if used for a long period of time. Discuss any concerns about this medication with your health care team.
- The use of this medication in men or women may cause harm to the unborn baby if pregnancy occurs. Let your health care team know if you or your partner is pregnant, becomes pregnant during treatment, or if you are breastfeeding
- If there is ANY chance that you or your partner may become pregnant, you and your partner together must:► Use 2 effective forms of birth control at the same time while taking this drug: Keep using birth control until 8 weeks after the last dose. Discuss with your healthcare team.
- Do not breastfeed while taking this drug and for 2 weeks after the last dose.
- This medication may affect fertility (ability to get pregnant)
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Take it exactly as directed by your doctor. Make sure you understand the instructions.
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Do not crush or chew the tablets.
- Take the dose at about the same time each day, preferably in the morning, either always with food or always without food.
- If you miss a dose, take it if it is within 6 hours of the missed dose, otherwise skip this and take the next dose on the following day at its usual scheduled time. Do not double the dose to make up for the forgotten one.
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This medication can interact with other medications and can result in the treatment not working as well or cause severe side effects.
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Make sure your health care team knows about all your medications (prescription, over-the-counter, herbals and supplements). Check with your health care team before starting or stopping any of them.
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Do not eat or drink grapefruit, starfruit, Seville oranges or their juices (or products that contain these) while on this treatment. They may increase side effects.
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For mild aches and pain:
- You may take acetaminophen (Tylenol®) tablets. Ask your health care team about the right dose for you.
- Ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or aspirin (acetylsalicylic acid, ASA), including low dose aspirin for heart conditions, may increase your chance of bleeding.
- Talk to your health care team before you start or stop these medications.
- If you feel unwell, take your temperature before taking any of these medications. They may hide a fever.
- Talk to your health care team or go to the closest emergency room right away if you have a fever. See the Fever pamphlet for more information.
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Drinking alcohol and smoking during your treatment may increase some side effects and make your medication less effective. Speak to your health care team about smoking and drinking alcohol while on treatment.
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Keep this medication in the original packaging at room temperature in a dry place, away from heat and light. Keep out of sight and reach of children and pets.
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Do not throw out any unused medications at home. Bring them to your pharmacy to be thrown away safely.
You may not have all of the side effects below. You may have side effects that are not listed.
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Mouth sores You may have round, painful, white or gray sores inside your mouth. They can occur on the tongue, lips, gums, or inside your cheeks. In more severe cases they may make it hard swallow, eat or to brush your teeth. They usually last 1 to 2 weeks. To help prevent mouth sores:
If you have mouth sores:
See the Mouth Care pamphlet for more information. |
Contact your health care team as soon as possible | ||||
Fatigue (tiredness)
See our Fatigue pamphlet for more information. |
Contact your health care team if no improvement or if severe | ||||
Cough; feeling short of breath You may have cough and feel short of breath without any signs of infection, such as a sore throat or a stuffed nose. |
Contact your health care team if no improvement or if severe | ||||
Diarrhea May happen days to weeks after you get your treatment. If you have diarrhea :
See the Diarrhea pamphlet for more information. |
Contact your health care team if no improvement or if severe | ||||
Rash; dry, itchy skin Rash may be severe in some rare cases and cause your skin to blister or peel. If this happens, get emergency medical help right away. To prevent and treat dry skin,
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Contact your health care team if no improvement or if severe | ||||
Nausea and vomiting (generally mild) May occur in hours to days after your treatment. If you have nausea or vomiting:
Also see Nausea & Vomiting pamphlet for more information. |
Contact your healthcare team if no improvement or if severe | ||||
Abnormal liver lab tests (may be severe)
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Contact your health care team if no improvement or if severe | ||||
Low appetite
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Contact your health care team if no improvement or if severe | ||||
Mild swelling in arms and legs; puffiness To help prevent swelling :
If you have swelling in your legs, keep your feet up when sitting. |
Contact your health care team if no improvement or if severe |
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Headache; mild joint, muscle pain or cramps
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Contact your health care team if no improvement or if severe | ||||
High blood sugar
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Contact your health care team as soon as possible | ||||
Lung problems You may have a cough, breathing problems, chest pain or cough up blood. |
Get emergency medical help right away | ||||
Taste changes
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Contact your health care team if no improvement or if severe | ||||
Unusual bleeding or bruising You may have black stools, cough up blood, blood in your urine, purple or red dots on your skin or bleeding that will not stop. Fever, chills, infection You have a fever if your temperature taken in your mouth (oral temperature) is:
While you are getting treatment:
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Get emergency medical help right away |
Other rare, but serious side effects are possible.
If you experience ANY of the following, speak to your cancer health care provider or get emergency medical help right away:
- signs of an allergy such as fever, itchiness, rash, swollen lips, face or tongue, chest and throat tightness.
- pain, swelling and hardening of the vein in your arm or leg
- irregular heartbeat, shortness of breath, chest pain, fainting spells or swelling in your legs, ankles and belly
- severe belly pain, bloating or feeling of fullness and severe constipation
- severe muscle pain or weakness and dark-coloured pee
- lower back pain, swelling, pee less than usual and have unusual weight gain
- sudden and severe tiredness and shortness of breath during mild activity
- wounds that do not heal well
For more links on how to manage your symptoms go to https://www.cancercareontario.ca/en/symptom-management.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.