Strategies of Sequential Therapies in Unresectable, Metastatic Colorectal Cancer Treated with Palliative Intent

Patient Population

Adult patients (≥18 years old) with unresectable metastatic colorectal cancer.

Intended Guideline Users

Clinicians and healthcare providers involved in the management of patients with unresectable, metastatic colorectal cancer treated with palliative intent.

Research Question(s)

What is the impact of different strategies of sequential and combination chemotherapy on efficacy (including overall survival), toxicity and quality of life in unresectable metastatic colorectal cancer treated with palliative intent?

The cytotoxic agents covered in this guideline include initial fluoropyrimidine (5-FU or capecitabine) either alone or in combination, irinotecan and oxaliplatin.