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Accelerated Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck

ID: 5-6c Nov 2000
Type of Content: Guidelines & Advice, Clinical
Document Status: Education and Information
Authors:
Members of the Head and Neck Cancer Disease Site Group

Patient Population

Adult patients with newly diagnosed, locally advanced (stage III-IV) squamous cell carcinoma of the head and neck (SCCHN) who are deemed suitable for radical radiotherapy with curative intent.

Research Question(s)

  1. Does accelerated radiotherapy improve loco-regional control or survival compared with conventionally fractionated radiotherapy in patients with newly diagnosed, locally advanced (stage III-IV) squamous cell carcinoma of the head and neck who are deemed suitable for radiotherapy with curative intent?
  2. What is the toxicity associated with accelerated fractionation?
  3. Can these novel regimens enhance the therapeutic ratio comparing benefits to toxicity?
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