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Adjuvant Radiotherapy in Women with Stage I Endometrial Cancer

ID: 4-10 Aug 2013
Type of Content: Guidelines & Advice, Clinical
Document Status: Education and Information
Members of the Gynecology Cancer Disease Site Group

Patient Population

Women with newly diagnosed stage I endometrial cancer who have undergone surgery, either complete surgical staging or total abdominal hysterectomy and bilateral salpingo-oophorectomy.

Of interest are outcomes reported by risk of recurrence: low risk (stage IA, IB, grades 1 & 2), intermediate risk (stage IC, grades 1 & 2, or stage IA, IB, grade 3), or high risk (stage IC, grade 3).

Research Question(s)

What is the role of adjuvant radiotherapy in women with stage I endometrial cancer? Specifically, are there subgroups of patients with stage I endometrial cancer who benefit from adjuvant radiotherapy? If so, which radiotherapy treatment is recommended?

Outcomes of interest are survival, pelvic control, ultimate pelvic control, and toxicity.

pdf download Full Report (PDF) (818.26 KB)