Adjuvant Radiotherapy in Women with Stage I Endometrial Cancer

Patient Population

Women with newly diagnosed stage I endometrial cancer who have undergone surgery, either complete surgical staging or total abdominal hysterectomy and bilateral salpingo-oophorectomy.

Of interest are outcomes reported by risk of recurrence: low risk (stage IA, IB, grades 1 & 2), intermediate risk (stage IC, grades 1 & 2, or stage IA, IB, grade 3), or high risk (stage IC, grade 3).

Research Question(s)

What is the role of adjuvant radiotherapy in women with stage I endometrial cancer? Specifically, are there subgroups of patients with stage I endometrial cancer who benefit from adjuvant radiotherapy? If so, which radiotherapy treatment is recommended?

Outcomes of interest are survival, pelvic control, ultimate pelvic control, and toxicity.