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Fecal Immunochemical Tests Compared With Guaiac Fecal Occult Blood Tests for Population-Based Colorectal Cancer Screening

ID: 15-8 Nov 2011
Type of Content: Guidelines & Advice, Clinical
Document Status: Education and Information
FIT Guidelines Expert Panel

Guideline Objective

To evaluate the existing evidence concerning fecal immunochemical test (FIT) to inform the decision on how to replace the current guaiac fecal occult blood test (gFOBT) with a FIT in Ontario’s ColonCancerCheck Program.

Intended Guideline Users

Primary care providers, other healthcare practitioners, and policy makers responsible for the design and implementation of colorectal cancer screening programs.

Research Question(s)

To address the guideline objective, the following three clinical issues were considered:

  1. FIT Performance Factors What are the performance characteristics (sensitivity, specificity, positivity, and positive predictive value [PPV]) of FIT when used to detect colorectal cancer (CRC)?
  2. FIT Kit Usability Factors What FIT kit factors affect acceptability by users (e.g., card versus vial collection FIT, medication use)?
  3. Specimen Stability What factors affect specimen stability?
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