inotuzumab ozogamicin
Other Name: Besponsa®
mixed into larger bags of fluids
For treating a certain type of blood cancer called acute lymphoblastic leukemia (ALL)
- Tell your health care team if you have or had significant medical condition(s), such as:
- liver, pancreas or gallbladder problems
- if you have had or will have a stem cell transplant
- heart problems, including irregular heartbeat
- liver, pancreas or gallbladder problems
Remember to:
- Tell your health care team about all of the other medications you are taking.
- Keep taking other medications that have been prescribed for you, unless you have been told not to by your health care team.
Talk to your health care team about:
How this treatment may affect your sexual health.
How this treatment may affect your ability to have a baby, if this applies to you.
This treatment may harm an unborn baby. Tell your health care team if you or your partner are pregnant, become pregnant during treatment, or are breastfeeding.
- If there is any chance of pregnancy happening, you and your partner together must:
- Use 2 effective forms of birth control at the same time while taking this drug.
- For women: Keep using birth control for at least 8 months after the last dose, unless your health care team told you differently.
- For men with a partner that has a chance of becoming pregnant: Keep using birth control for at least 5 months after the last dose, unless your health care team told you differently.
- Talk to your health care team about which birth control options are best for you and/or your partner.
- Use 2 effective forms of birth control at the same time while taking this drug.
- Do not breastfeed while using this drug and for at least 2 months after treatment ends.
This drug is given by injection into a vein.
- Talk to your health care team about your treatment schedule.
- If you missed your treatment appointment, talk to your health care team to find out what to do.
To Prevent Allergic Reaction
- You will be given medications before your treatment to help prevent allergic reactions before they start.
- There are different types of medications to stop allergic reactions. They are called:
- antihistamines (such as diphenhydramine or Benadryl®)
- analgesics/antipyretics (such as acetaminophen or Tylenol®)
- corticosteroids (such as prednisone)
- antihistamines (such as diphenhydramine or Benadryl®)
To Prevent Tumor Lysis Syndrome (TLS)
TLS can happen when a large number of cancer cells die quickly and your body cannot get rid of them fast enough. TLS can make you very sick. Ask your health care team if you are at risk for TLS.
If you are at risk for TLS, you may be given medications before your treatment to help prevent it.
- These are called anti-uricemics (such as allopurinol), or others.
Will this medication interact with other medications or natural health products?
This medication can interact with other medications, vitamins, foods and natural health products. Interactions can make the treatment not work as well or cause severe side effects.
Tell your health care team about all of your:
prescription and over-the-counter (non-prescription) medications and all other drugs, such as marijuana (medical or recreational)
natural health products such as vitamins, herbal teas, homeopathic medicines, and other supplements
Check with your health care team before starting or stopping any of them.
What should I do if I feel unwell, have pain, a headache or a fever?
Always check your temperature to see if you have a fever before taking any medications for fever or pain (such as acetaminophen (Tylenol®) or ibuprofen (Advil®)).
Fever can be a sign of infection that may need treatment right away.
If you take these medications before you check for fever, they may lower your temperature and you may not know you have an infection.
How to check for fever:
Keep a digital (electronic) thermometer at home and take your temperature if you feel hot or unwell (for example, chills, headache, mild pain).
- You have a fever if your temperature taken in your mouth (oral temperature) is:
- 38.3°C (100.9°F) or higher at any time
OR
- 38.0°C (100.4°F) or higher for at least one hour.
- 38.3°C (100.9°F) or higher at any time
If you do have a fever:- Try to contact your health care team. If you are not able to talk to them for advice, you MUST get emergency medical help right away.
- Ask your health care team for the Fever pamphlet for more information.
If you do not have a fever but have mild symptoms such as headache or mild pain:
Ask your health care team about the right medication for you. Acetaminophen (Tylenol®) is a safe choice for most people.
Talk to your health care team before you start taking Ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or ASA (Aspirin®), as they may increase your chance of bleeding or interact with your cancer treatment.
Talk to your health care team if you already take low dose aspirin for a medical condition (such as a heart problem). It may still be safe to take.
What to DO while on this medication:
- DO check with your health care team before getting any vaccinations, surgery, dental work or other medical procedures. Some vaccines cannot be given before, during, and for months after treatment with inotuzumab ozogamicin.
- DO take special care with driving, operating machinery or performing any other tasks or actions that call for alertness while on inotuzumab ozogamicin, because it may cause tiredness.
What NOT to DO on this medication:
- DO NOT smoke or drink alcohol while on treatment without talking to your health care team first. Smoking and drinking can make side effects worse and make your treatment not work as well.
The following table lists side effects that you may have when getting inotuzumab ozogamicin. The table is set up to list the most common side effects first and the least common last. It is unlikely that you will have all of the side effects listed and you may have some that are not listed.
Read over the side effect table so that you know what to look for and when to get help. Keep this paper during your treatment so that you can refer to it if you need to.
Very Common Side Effects (50 or more out of 100 people) | |
Side effects and what to do | When to contact health care team |
Low neutrophils (white blood cells) in the blood (neutropenia) When neutrophils are low, you are at risk of getting an infection more easily. Ask your health care team for the Neutropenia (Low white blood cell count) pamphlet for more information. What to look for?
You have a fever if your temperature taken in your mouth (oral temperature) is:
What to do? If your health care team has told you that you have low neutrophils:
If you have a fever: If you have a fever, try to contact your health care team. If you are unable to talk to the team for advice, you must get emergency medical help right away. | If you have a fever, try to contact your health care team. If you are unable to talk to the team for advice, you MUST get emergency medical help right away. |
Low platelets in the blood When your platelets are low, you are at risk for bleeding and bruising. Ask your health care team for the Low Platelet Count pamphlet for more information. What to look for?
What to do? If your health care team has told you that you have low platelets:
If you have signs of bleeding:
If you have bleeding that does not stop or is severe (very heavy), you must get emergency medical help right away. | Talk to your health care team if you have any signs of bleeding. If you have bleeding that doesn’t stop or is severe (very heavy), you MUST get emergency help right away. |
Common Side Effects (25 to 49 out of 100 people) | |
Side effects and what to do | When to contact health care team |
Fatigue What to look for?
What to do?
Ask your health care team for the Fatigue pamphlet for more information. | Talk to your health care team if it does not improve or if it is severe |
Headache, Flu-like symptoms You may feel like you have the flu for around 2 days after your IV treatment. These flu-like symptoms may not be signs of an infection. What to look for?
What to do?
| Talk to your health care team if it does not improve or if it is severe |
Nausea and vomiting What to look for?
What to do? To help prevent nausea:
| Talk to your health care team if nausea lasts more than 48 hours or vomiting lasts more than 24 hours or if severe |
Liver problems Your health care team may check your liver function with a blood test. The liver changes do not usually cause any symptoms. What to look for?
If you have any symptoms of liver problems, get emergency medical help right away. | Get emergency medical help right away |
Less Common Side Effects (10 to 24 out of 100 people) | |
Side effects and what to do | When to contact health care team |
Pains or cramps in the belly What to look for?
| Talk to your health care team if it does not improve or if it is severe |
Diarrhea What to look for?
What to do? If you have diarrhea:
| Talk to your health care team if no improvement after 24 hours of taking diarrhea medication or if severe (more than 7 times in one day) |
Constipation What to look for?
What to do? To help prevent constipation:
To help treat constipation:
Ask your health care team for the Constipation Pamphlet for more information. | Talk to your health care team if it does not improve or if it is severe |
Mouth sores What to look for?
What to do? To help prevent mouth sores:
Ask your health care team for the Oral Care (Mouth Care) pamphlet for more information. | Talk to your health care team as soon as you notice mouth or lip sores or if it hurts to eat, drink or swallow |
Low appetite What to look for?
Ask your health care team for the Loss of Appetite pamphlet for more information. | Talk to your health care team if it does not improve or if it is severe |
Other rare, but serious side effects are possible.
If you experience ANY of the following, speak to your cancer health care provider or get emergency medical help right away:
- flushing, itchiness, rash, swollen lips, face or tongue, wheezing, chest and throat tightness, during or shortly after the drug is given
- irregular heartbeat, dizziness or fainting spells
- lower back pain, leg swelling, pee less than usual
- muscle twitching, severe weakness, cramping or feel confused
- rapid, unexpected weight gain; pain in upper right side of belly, swelling in the belly
- pain in the centre of your belly that may extend to your back
Who do I contact if I have questions or need help?My cancer health care provider is: ______________________________________________ During the day I should contact:________________________________________________ Evenings, weekends and holidays:______________________________________________
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Other Notes:
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June 2021 Updated "What is this medication for" section
For more links on how to manage your symptoms go to www.cancercareontario.ca/symptoms.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.