Published Research

A large body of research has been produced by scientists, clinical leads, scientific leads and/or staff working for or funded by Cancer Care Ontario. Much of the research has been published in peer-reviewed scientific journals.

For a list of research from across CCO, including articles about chronic kidney disease and other health related topics, visit PubMed.

Featured Cancer Research Articles

Crosina J, Wright F, Irish J, Rashid M, Martin T, Hirpara DH, Hunter A, Sundaresan S. Long Term Impact of Regionalization of Thoracic Oncology Surgery. Ann Thorac Surg. 2025 Feb;119(2):460-469. doi: 10.1016/j.athoracsur.2024.10.002. Epub 2024 Oct 21. PMID: 39442904.

de Bondt D, Naslazi E, Jansen E, Kupets R, McCurdy B, Stogios C, de Kok I, Hontelez J. Validating the predicted impact of HPV vaccination on HPV prevalence, cervical lesions, and cervical cancer: A systematic review of population level data and modelling studies. Gynecol Oncol. 2025 Mar 17;195:134-143. doi: 10.1016/j.ygyno.2025.03.008. Epub ahead of print. PMID: 40101607.

DeBono NL, Everest L, Richardson DB, Berriault C, Yeo RE, Meeds MA, Arrandale V, Demers PA. Impact of Interventions to Prevent Asbestos-Related Respiratory Disease in an Exposed Worker Registry Using a Simplified G-computation. Am J Epidemiol. 2025 Feb 27:kwaf040. doi: 10.1093/aje/kwaf040. Epub ahead of print. PMID: 40036898.

Koehoorn M, McLeod CB, Fan J, Arrandale VH, Davies HW, Dement JM, Pahwa M, Peters CE, Stayner L, Straif K, Demers PA. Occupational asbestos exposure and gastrointestinal cancers: systematic review and meta-analyses. Occup Environ Med. 2025 Feb 12;81(12):639-646. doi: 10.1136/oemed-2024-109707. PMID: 39929711.

Metser U, Lukovic J, Mesci A, MacCrostie P, Chan R, Mak V, Avery L, Singnurkar A, Langer DL, Ly K, Kohan A. [18F]-FDG PET/CT in the Initial Staging of Squamous Cell Cancer of the Anal Canal: Results of a Prospective Multicenter Registry. J Nucl Med. 2025 Apr 1;66(4):537-542. doi: 10.2967/jnumed.124.269289. PMID: 40049747.

Mittal A, Everest L, Patel D, Zhan LJ, Brown MC, Zaeimi F, Schmid S, Khan K, Dietrich K, Balaratnam K, de Santayana MG, Eng L, Sacher AG, Shepherd FA, Leighl NB, Cho J, De Perrot M, Liu G. Health utility and symptom scores in patients with advanced malignant pleural mesothelioma treated in a real-world setting. JTO Clin Res Rep. 2025 Feb 12. doi: 10.1016/j.jtocrr.2025.100802. Epub ahead of print.

Mittmann N, Seung SJ, Ante Z, Liu N, Yong JH, Yusuf A, Chiarelli AM, Earle CC. Updated breast cancer costs for women by disease stage and phase of care using population-based databases. Health Rep. 2024 Nov 20;35(11):3-11. doi: 10.25318/82-003-x202401100001-eng. PMID: 39570813.

Muñoz C, Beca JM, Dvorani E, Mercer RE, Arias J, Adamic A, Gavura S, Chan KKW. Comparative Safety and Effectiveness of Bevacizumab Biosimilars to Originator for the Treatment of Metastatic Colorectal Cancer. J Natl Compr Canc Netw. 2024 Dec;22(10):677-684. doi: 10.6004/jnccn.2024.7053. PMID: 39602878.

Pahwa M, Abelson J, Schwartz L, Demers PA, Shen K, Shaikh H, Vanstone M. Public perspectives on ethical issues in lung cancer screening policy design and implementation in Ontario, Canada. Ethics Med Public Health. 2025 Jan 1;33:101061.

Reveiz M, Bouhouita-Guermech S, Blackmore KM, Chiquette J, Demers É, Dorval M, Lambert-Côté L, Nabi H, Pashayan N, Soucy P, Turgeon A, Walker MJ, Knoppers BM, Chiarelli A, Simard J, Joly Y. Genetic Discrimination in Insurance and Employment based on Personalized Risk Stratification for breast cancer screening. Front Genet. 2025 Mar 5;16:1481863. doi: 10.3389/fgene.2025.1481863. PMID: 40110039

Seung SJ, Mittmann N, Ante Z, Liu N, Blackmore KM, Richard ES, Wong A, Walker MJ, Earle CC, Simard J, Chiarelli AM. Evaluating Real World Health System Resource Utilization and Costs for a Risk-Based Breast Cancer Screening Approach in the Canadian PERSPECTIVE Integration and Implementation Project. Cancers (Basel). 2024 Sep 18;16(18):3189. doi: 10.3390/cancers16183189. PMID: 39335160.

Tan VS, Metser U, Rashid M, Langer DL, MacCrostie P, Green B, Mak V, Kulkarni GS, Shayegan B, Pautler S, Lavallée LT, Finelli A, Klotz L, Hagerty M, Bauman G. Association of marginalization and PSMA-PET in prostate cancer: An analysis of the Ontario PSMA-PET Registry for Recurrent Prostate Cancer. Can Urol Assoc J. 2025 Feb 24. doi: 10.5489/cuaj.9034. Epub ahead of print. PMID: 40031949.

Walker MJ, Neely A, Antoniou AC, Broeders MJM, Brooks JD, Carver T, Chiquette J, Easton DF, Eisen A, Eloy L, Evans DGR, Fienberg S, Joly Y, Kim RH, Knoppers BM, Lofters AK, Nabi H, Pashayan N, Stockley TL, Dorval M, Simard J, Chiarelli AM. Barriers and Facilitators to Delivering Multifactorial Risk Assessment and Communication for Personalized Breast Cancer Screening: A Qualitative Study Exploring Implementation in Canada. Curr Oncol. 2025 Mar 10;32(3):155. doi: 10.3390/curroncol32030155. PMID: 40136359.

Wesselink E, Gauderman W, Berndt SI, Brenner H, Buchanan DD, Campbell PT, Chan AT, Chang-Claude J, Cotterchio M, Gunter MJ, Hoffmeister M, Joshi AD, Newton CC, Pai RK, Pellatt AJ, Phipps AI, Song M, Um CY, van Guelpen B, White E, Peters U, van Duijnhoven FJB. Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients. BJC Rep. 2024;2(1):63. doi: 10.1038/s44276-024-00077-3. Epub 2024 Sep 2. PMID: 39233917.

Articles by external researchers utilizing Cancer Care Ontario data

AlGhamdi S, Ahimsadasan N, Kong W, Brundage M, Eisenhauer EA, Parker CM, Robinson A, Giles A, Digby GC. Factors Influencing the Timeliness and Completeness of Appropriate Staging Investigations for Patients with Stage I-III Lung Cancer in Southeastern Ontario. Curr Oncol. 2024 Oct 11;31(10):6073-6084. doi: 10.3390/curroncol31100453. PMID: 39451757.

Cheung DC, Martin LJ, Timilshina N, Komisarenko M, Richard PO, Alibhai SMH, Sussman J, Mittmann N, Finelli A. Using real-world, population-level data to assess the uptake of active surveillance for low-grade prostate cancer before and after the release of clinical guidelines. Can Urol Assoc J. 2025 Feb 24. doi: 10.5489/cuaj.9019. Epub ahead of print. PMID: 40031948.

Eom A, Kirkwood D, Pond G, Hodgson N, Doumouras A, Bogach J, Whelan T, Levine M, Parvez E. Radiation therapy and immigration status in women with breast cancer. Radiother Oncol. 2025 Apr;205:110774. doi: 10.1016/j.radonc.2025.110774. Epub 2025 Jan 31. PMID: 39894258.

Gaebe K, Erickson AW, Chen S, Menjak IB, Lok BH, Sahgal A, Chan KKW, Das S. Brain metastasis burden and management in patients with small cell lung cancer in Canada: a retrospective, population-based cohort study. EClinicalMedicine. 2024 Oct 3;77:102871. doi: 10.1016/j.eclinm.2024.102871. PMID: 39416386.

Gorodensky JH, Davis L, Griffiths R, Ayonrinde O, Webber C, Hanna TP, Coburn N, Mahar AL. Inequities in the Time to Colon Cancer Diagnosis Among Individuals With Severe Psychiatric Illness. Cancer Med. 2025 Feb;14(4):e70623. doi: 10.1002/cam4.70623. PMID: 39960259.

Grewal K, Calzavara A, McLeod SL, Eskander A, Savage DW, Thompson C, Borgundvaag B, Ovens H, Cheskes S, de Wit K, Irish J, Krzyzanowska MK, Walsh R, Mohindra R, Thiruganasambandamoorthy V, Sutradhar R. Emergency department use before cancer diagnosis in Ontario, Canada: a population-based study. CMAJ. 2024 Nov 3;196(37):E1252-E1261. doi: 10.1503/cmaj.240952. PMID: 39496352.

Mohyuddin GR, Mian H, Gayowsky A, Seow H, Chakraborty R, Pond GR, Al Hadidi S, Visram A. Impact of age on treatment utilization for newly diagnosed multiple myeloma: a nationwide retrospective cohort study. Blood Cancer J. 2024 Oct 16;14(1):181. doi: 10.1038/s41408-024-01164-x. PMID: 39414772.

Motamedi N, McClure A, Power N, Pautler S, Gien L, Welk B, McGee J. Evaluating trends in radical prostatectomy approach and 30-day complication rate in Ontario from 2010-2019. Can Urol Assoc J. 2025 Feb;19(2):42-48. doi: 10.5489/cuaj.8636. PMID: 39418489.

Shakil H, Malhotra AK, Essa A, Landry AP, Suppiah S, Sahgal A, Dea N, Zadeh G, Fehlings MG, Witiw CD, Wilson JR. Chordoma incidence, treatment, and survival in the 21st century: a population-based Ontario cohort study. J Neurosurg. 2024 Oct 18;142(3):702-711. doi: 10.3171/2024.6.JNS24426. PMID: 39423422.

Taslimi S, Brogly S, Hanna T, Shellenberger J, Whitehead M, Alkins RD. A population-based cohort study of Glioblastoma (WHO grade 4 gliomas) in Ontario: continued improvement in care over 25 years. World Neurosurg. 2025 Feb 21:123821. doi: 10.1016/j.wneu.2025.123821. Epub ahead of print. PMID: 39987972.

Waddingham CM, Hinton P, Villeneuve PJ, Brook JR, Lavigne E, Larsen K, King WD, Wen D, Meng J, Zhang J, Galarneau E, Harris SA. Exposure to ambient polycyclic aromatic hydrocarbons and early-onset female breast cancer in a case-control study in Ontario, Canada. Environ Epidemiol. 2024 Oct 8;8(5):e333. doi: 10.1097/EE9.0000000000000333. PMID: 39386012.