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Published Research

A large body of research has been produced by scientists, clinical leads, scientific leads and/or staff working for or funded by Cancer Care Ontario. Much of the research has been published in peer-reviewed scientific journals.

For a list of research from across CCO, including articles about chronic kidney disease and other health related topics, visit PubMed.

Featured Cancer Research Articles

Alarie S, Hagan J, Dalpé G, Faraji S, Mbuya-Bienge C, Nabi H, Pashayan N, Brooks JD, Dorval M, Chiquette J, Eloy L, Turgeon A, Lambert-Côté L, Paquette JS, Walker MJ, Lapointe J, Granados Moreno P, Blackmore K, Wolfson M, Broeders M, The Perspective I I Study Group, Knoppers BM, Chiarelli AM, Simard J, Joly Y. Risk-Stratified Approach to Breast Cancer Screening in Canada: Women's Knowledge of the Legislative Context and Concerns about Discrimination from Genetic and Other Predictive Health Data. J Pers Med. 2021 Jul 27;11(8):726. doi: 10.3390/jpm11080726. PMID: 34442372.

Arnold M, Morgan E, Bardot A, Rutherford MJ, Ferlay J, Little A, Møller B, Bucher O, De P, Woods RR, Saint-Jacques N, Gavin AT, Engholm G, Achiam MP, Porter G, Walsh PM, Vernon S, Kozie S, Ramanakumar AV, Lynch C, Harrison S, Merrett N, O'Connell DL, Mala T, Elwood M, Zalcberg J, Huws DW, Ransom D, Bray F, Soerjomataram I. International variation in oesophageal and gastric cancer survival 2012-2014: differences by histological subtype and stage at diagnosis (an ICBP SURVMARK-2 population-based study). Gut. 2021 Nov 25:gutjnl-2021-325266. doi: 10.1136/gutjnl-2021-325266. Epub ahead of print. PMID: 34824149.

Beca JM, Dai WF, Pataky RE, Tran D, Dvorani E, Isaranuwatchai W, Peacock S, Alvi R, Cheung WY, Earle CC, Gavura S, Chan KKW. Real-world Safety of Bevacizumab with First-line Combination Chemotherapy in Patients with Metastatic Colorectal Cancer: Population-based Retrospective Cohort Studies in Three Canadian Provinces. Clin Oncol (R Coll Radiol). 2022 Jan;34(1):e7-e17. doi: 10.1016/j.clon.2021.08.009. Epub 2021 Aug 26. PMID: 34456106.

Beca JM, Walsh S, Raza K, Hubay S, Robinson A, Mow E, Keech J, Chan KKW. Cost-effectiveness analysis of first-line treatment with crizotinib in ROS1-rearranged advanced non-small cell lung cancer (NSCLC) in Canada. BMC Cancer. 2021 Oct 29;21(1):1162. doi: 10.1186/s12885-021-08746-z. PMID: 34715804.

Chang VC, Cotterchio M, De P, Tinmouth J. Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada. Cancer Causes Control. 2021 Oct;32(10):1063-1083. doi: 10.1007/s10552-021-01456-8. Epub 2021 Jun 13. PMID: 34120288.

Cheung MC, Franco BB, Meti N, Thawer A, Tahmasebi H, Shankar A, Loblaw A, Wright FC, Fox C, Peek N, Sim V, Singh S. Delivery of Virtual Care in Oncology: Province-Wide Interprofessional Consensus Statements Using a Modified Delphi Process. Curr Oncol. 2021 Dec 13;28(6):5332-5345. doi: 10.3390/curroncol28060445. PMID: 34940084.

Chiarelli AM, Walker MJ, Espino-Hernandez G, Gray N, Salleh A, Adhihetty C, Gao J, Fienberg S, Rey MA, Rabeneck L. Adherence to guidance for prioritizing higher risk groups for breast cancer screening during the COVID-19 pandemic in the Ontario Breast Screening Program: a descriptive study. CMAJ Open. 2021 Dec 21;9(4):E1205-E1212. doi: 10.9778/cmajo.20200285. PMID: 34933878.

Dai WF, Arciero V, Craig E, Fraser B, Arias J, Boehm D, Bosnic N, Caetano P, Chambers C, Jones B, Lungu E, Mitera G, Potashnik T, Reiman A, Ritcher T, Beca JM, Denburg A, Mercer RE, Parmar A, Tadrous M, Takhar P, Chan KKW, On Behalf Of The CanREValue Collaboration Reassessment And Uptake Working Group. Considerations for Developing a Reassessment Process: Report from the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration's Reassessment and Uptake Working Group. Curr Oncol. 2021 Oct 16;28(5):4174-4183. doi: 10.3390/curroncol28050354. PMID: 34677272.

Dai WF, Craig E, Fraser B, Chambers A, Mai H, Brown MB, Earle CC, Evans WK, Geirnaert M, Taylor M, Trudeau M, Sperber D, Beca JM, Denburg A, Mercer RE, Parmar A, Tadrous M, Takhar P, Chan KKW, On Behalf Of The CanREValue Collaboration. Building a National Reassessment Process for Oncology Drugs: Lessons Learned by the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration through a Simulated Reassessment Exercise. Curr Oncol. 2021 Nov 12;28(6):4645-4654. doi: 10.3390/curroncol28060392. PMID: 34898572.

DeBono NL, Warden H, Logar-Henderson C, Shakik S, Dakouo M, MacLeod J, Demers PA. Incidence of mesothelioma and asbestosis by occupation in a diverse workforce. Am J Ind Med. 2021 Jun;64(6):476-487. doi: 10.1002/ajim.23245. Epub 2021 Apr 8. PMID: 33834530.

Brooks JD, Nabi HH, Andrulis IL, Antoniou AC, Chiquette J, Després P, Devilee P, Dorval M, Droit A, Easton DF, Eisen A, Eloy L, Fienberg S, Goldgar D, Hahnen E, Joly Y, Knoppers BM, Lofters A, Masson JY, Mittmann N, Paquette JS, Pashayan N, Schmutzler R, Stockley T, Tavtigian SV, Walker MJ, Wolfson M, Chiarelli AM, Simard J. Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I). J Pers Med. 2021 Jun 4;11(6):511. doi: 10.3390/jpm11060511. PMID: 34199804.

Dimou N, Mori N, Harlid S, Harbs J, Martin RM, Smith-Byrne K, Papadimitriou N, Bishop DT, Casey G, Colorado-Yohar SM, Cotterchio M, Cross AJ, Le Marchand L, Lin Y, Offit K, Onland-Moret NC, Peters U, Potter JD, Rohan TE, Weiderpass E, Gunter MJ, Murphy N. Circulating levels of testosterone, sex hormone binding globulin and colorectal cancer risk: observational and Mendelian randomization analyses. Cancer Epidemiol Biomarkers Prev. 2021 Jul;30(7):1336-1348. doi: 10.1158/1055-9965.EPI-20-1690. Epub 2021 Apr 20. PMID: 33879453.

Dossa F, Meggetto O, Yakubu M, Zhang DDQ, Baxter NN. Sedation practices for routine gastrointestinal endoscopy: a systematic review of recommendations. BMC Gastroenterol. 2021 Jan 7;21(1):22. doi: 10.1186/s12876-020-01561-z. PMID: 33413147.

Habbous S, Yermakhanova O, Forster K, Holloway CMB, Darling G. Variation in Diagnosis, Treatment, and Outcome of Esophageal Cancer in a Regionalized Care System in Ontario, Canada. JAMA Netw Open. 2021 Sep 1;4(9):e2126090. doi: 10.1001/jamanetworkopen.2021.26090. PMID: 34546371.

Hirte H, Yao X, Ferguson SE, May T, Elit L. An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline: Consolidation or Maintenance Systemic Therapy for Newly Diagnosed Stage II, III, or IV Epithelial Ovary, Fallopian Tube, or Primary Peritoneal Carcinoma. Curr Oncol. 2021 Mar 1;28(2):1114-1124. doi: 10.3390/curroncol28020107. PMID: 33804587.

Howell D, Powis M, Kirkby R, Amernic H, Moody L, Bryant-Lukosius D, O'Brien MA, Rask S, Krzyzanowska M. Improving the quality of self-management support in ambulatory cancer care: a mixed-method study of organisational and clinician readiness, barriers and enablers for tailoring of implementation strategies to multisites. BMJ Qual Saf. 2022 Jan;31(1):12-22. doi: 10.1136/bmjqs-2020-012051. Epub 2021 Mar 16. PMID: 33727415.

Jamal S, Jones C, Walker J, Mazereeuw M, Sheppard AJ, Henry D, Marrett LD. Cancer in First Nations people in Ontario, Canada: Incidence and mortality, 1991 to 2010. Health Rep. 2021 Jun 16;32(6):14-28. doi: 10.25318/82-003-x202100600002-eng. PMID: 34142787.

Jull J, Sheppard AJ, Hizaka A; Inuit Medical Interpreter Team, Barton G, Doering P, Dorschner D, Edgecombe N, Ellis M, Graham ID, Habash M, Jodouin G, Kilabuk L, Koonoo T, Roberts C; Mamisarvik Healing Centre Team. Experiences of Inuit in Canada who travel from remote settings for cancer care and impacts on decision making. BMC Health Serv Res. 2021 Apr 13;21(1):328. doi: 10.1186/s12913-021-06303-9. PMID: 33845810.

Meggetto O, Jembere N, Gao J, Walker MJ, Rey M, Rabeneck L, Murphy KJ, Kupets R; Ontario Cervical Screening Program / Colposcopy COVID-19 Working Group [members: Coulson M, McCurdy BR, Stogios C, Wallace J, Wang L]. The impact of the COVID-19 pandemic on the Ontario Cervical Screening Program, colposcopy and treatment services in Ontario, Canada: a population-based study. BJOG. 2021 Aug;128(9):1503-1510. doi: 10.1111/1471-0528.16741. Epub 2021 May 31. PMID: 33982870.

Milkovich J, Hanna T, Nessim C, Petrella TM, Weatherhead L, Chan AW, Irish JC, Murray C, Bannerman G, Holloway C, Forster K, Pazzano L, Wright FC, The Ontario Skin Cancer Advisory Committee. Restructuring Skin Cancer Care in Ontario: A Provincial Plan. Curr Oncol. 2021 Mar 12;28(2):1183-1196. doi: 10.3390/curroncol28020114. PMID: 33809399.

Mukkala AN, Song JB, Lee M, Boasie A, Irish J, Finelli A, Wei AC. A systematic review and meta-analysis of unplanned hospital visits and re-admissions following radical prostatectomy for prostate cancer. Can Can Urol Assoc J. 2021 Oct;15(10):E531-E544. doi: 10.5489/cuaj.6931. PMID: 33750517.

Naipaul RD, Mercer RE, Chan KKW, Yeung L, Forbes L, Gavura S. Clinician Perspectives of COVID-19-Related Cancer Drug Funding Measures in Ontario. Curr Oncol. 2021 Feb 26;28(2):1056-1066. doi: 10.3390/curroncol28020103. PMID: 33652898.

Nnorom O, Sappong-Kumankumah A, Olaiya OR, Burnett M, Akor N, Shi N, Wright P, Gebreyesus A, Gebremikael L, Lofters A. Afrocentric screening program for breast, colorectal, and cervical cancer among immigrant patients in Ontario. Can Fam Physician. 2021 Nov;67(11):843-849. doi: 10.46747/cfp.6711843. PMID: 34772714.

Papadakos J, Samoil D, Umakanthan B, Charow R, Jones JM, Matthew A, Nissim R, Sayal A, Giuliani ME. What are we doing to support informal caregivers? A scoping review of caregiver education programs in cancer care. Patient Educ Couns. 2021 Oct 23:S0738-3991(21)00671-6. doi: 10.1016/j.pec.2021.10.012. Epub ahead of print. PMID: 34810056.

Raphael MJ, Raskin W, Habbous S, Tai X, Beca J, Dai WF, Arias J, Forbes L, Gavura S, Biagi JJ, Earle CC, Chan KKW. The Association of Drug-Funding Reimbursement With Survival Outcomes and Use of New Systemic Therapies Among Patients With Advanced Pancreatic Cancer. JAMA Netw Open. 2021 Nov 1;4(11):e2133388. doi: 10.1001/jamanetworkopen.2021.33388. PMID: 34779846.

Ruan Y, Poirier AE, Pader J, Asakawa K, Lu C, Memon S, Miller AB, Walter SD, Villeneuve PJ, King WD, Volesky KD, Smith L, De P, Friedenreich CM, Brenner DR. Estimating the future cancer management costs attributable to modifiable risk factors in Canada. Can J Public Health. 2021 Dec;112(6):1083-1092. doi: 10.17269/s41997-021-00502-x. Epub 2021 May 25. PMID: 34036521.

Ruco A, Dossa F, Tinmouth J, Llovet D, Jacobson J, Kishibe T, Baxter N. Social Media and mHealth Technology for Cancer Screening: Systematic Review and Meta-analysis. J Med Internet Res. 2021 Jul 30;23(7):e26759. doi: 10.2196/26759. PMID: 34328423.

Tammemägi MC, Darling GE, Schmidt H, Llovet D, Buchanan DN, Leung Y, Miller B, Rabeneck L. Selection of individuals for lung cancer screening based on risk prediction model performance and economic factors - The Ontario experience. Lung Cancer. 2021 Jun;156:31-40. doi: 10.1016/j.lungcan.2021.04.005. Epub 2021 Apr 20. PMID: 33887677.

Tinmouth J, Llovet D, Sutradhar R, Tsiplova K, Roushani J, Lee A, Hader J, Rabeneck L, Paszat L. Two randomized controlled trials for colorectal cancer screening invitations developed using a behavioral science approach. Prev Med. 2021 Dec 23;155:106918. doi: 10.1016/j.ypmed.2021.106918. Epub ahead of print. PMID: 34953810.

Walker MJ, Hartman K, Majpruz V, Leung YW, Fienberg S, Rabeneck L, Chiarelli AM. The Impact of Radiologist Screening Mammogram Reading Volume on Performance in the Ontario Breast Screening Program. Can Assoc Radiol J. 2021 Aug 22:8465371211031186. doi: 10.1177/08465371211031186. Epub ahead of print. PMID: 34423685.

Walker MJ, Meggetto O, Gao J, Espino-Hernández G, Jembere N, Bravo CA, Rey M, Aslam U, Sheppard AJ, Lofters AK, Tammemägi MC, Tinmouth J, Kupets R, Chiarelli AM, Rabeneck L. Measuring the impact of the COVID-19 pandemic on organized cancer screening and diagnostic follow-up care in Ontario, Canada: A provincial, population-based study. Prev Med. 2021 Oct;151:106586. doi: 10.1016/j.ypmed.2021.106586. PMID: 34217413.

Webber C, Whitehead M, Eisen A, Holloway CMB, Groome PA. Factors associated with waiting time to breast cancer diagnosis among symptomatic breast cancer patients: a population-based study from Ontario, Canada. Breast Cancer Res Treat. 2021 May;187(1):225-235. doi: 10.1007/s10549-020-06051-0. Epub 2021 Jan 24. PMID: 33486544.

Young S, Metser U, Sistani G, Langer DL, Bauman G. Establishing a Provincial Registry for Recurrent Prostate Cancer: Providing Access to PSMA PET/CT in Ontario, Canada. Front Oncol. 2021 Aug 2;11:722430. doi: 10.3389/fonc.2021.722430. PMID: 34408985.