Published Research

A large body of research has been produced by scientists, clinical leads, scientific leads and/or staff working for or funded by Cancer Care Ontario. Much of the research has been published in peer-reviewed scientific journals.

For a list of research from across CCO, including articles about chronic kidney disease and other health related topics, visit PubMed.

Featured Cancer Research Articles

Barclay ME, McPhail S, Johnson SA, Swann R, Butler J, Finley CJ, Barisic A, Bennett D, Bucher O, Creighton N, Denny CA, Dewar RA, Donnelly DW, Downie L, Finn N, Habbous S, Huws DW, May L, Møller B, Morrison DS, Musto G, Nilssen Y, Saint-Jacques N, Shack L, Te Marvelde L, Tian X, Thomas RJS, Thomson CS, Walton R, Wong THT, Woods RR, You H, Lyratzopoulos G; ICBP Module 9 Ovarian Study Group. Chemotherapy use in ovarian cancer patients diagnosed 2012-2017 in Australia, Canada, Norway and the UK: An International Cancer Benchmarking Partnership (ICBP) population-based study. Cancer Epidemiol. 2025 Dec;99:102903. doi: 10.1016/j.canep.2025.102903. Epub 2025 Sep 11. PMID: 40940184.

Chan KK, Takhar P, Evans WK, Mercer RE, Denburg A, Beca J, Muñoz C, Gavura S, Cheung WY, Hoch J, Craig E, de Oliveira C, Geirnaert M, Trudeau M, Ahuja T, Peacock S, Dai WF, Isaranuwatchai W, Bombard Y, Chambers C, Earle CC, Alvi R, Pechlivanoglou P, Tadrous M. Development of a framework on the incorporation of real-world evidence (RWE) into cancer drug funding decisions in Canada: the Canadian Real-world Evidence for Value of Cancer Drugs (CanREValue) collaboration. BMJ Open. 2025 May 30;15(5):e096286. doi: 10.1136/bmjopen-2024-096286. PMID: 40447425.

de Bondt DD, Jansen EEL, Stogios C, McCurdy BR, Kupets R, Murphy J, Costescu D, Rabeneck L, Truscott R, Hontelez JAC, de Kok IMCM. Optimizing the Harms and Benefits of Cervical Screening in a Partially Vaccinated Population in Ontario, Canada: A Modeling Study. Med Decis Making. 2025 Jul;45(5):545-556. doi: 10.1177/0272989X251332597. Epub 2025 Apr 22. PMID: 40260498.

DeBono NL, Amar V, Hardy H, Schubauer-Berigan MK, Ruths D, King NB. A large language model-based tool for identifying relationships to industry in research on the carcinogenicity of benzene, cobalt, and aspartame. Environ Health. 2025 Sep 24;24(1):64. doi: 10.1186/s12940-025-01223-1. PMID: 40993649.

DeVuono IR, Posa S, Lafond NMC, Woodley BD, Coroiu A, Chaiton MO, Evans WK, Veldhuizen S, Zawertailo LA, Melamed OC, Eng L, George MM, Halligan MH, Silverman CB, Stewart A, Krames L, Bradley M, Hussain S, Selby P, Minian N. Exploring Practices for Implementing Smoking Cessation in Oncology Settings: A Rapid Systematic Review Update. Cancer Control. 2025 Jan-Dec;32:10732748251359835. doi: 10.1177/10732748251359835. Epub 2025 Aug 1. PMID: 40747640.

Dima DC, Boyko S, Torchetti T, McBain S, Benko S, Khan I, Ye XY, Quartey NK, Poznanski D, MacKinnon K, Papadakos J. Fertility Information Perceptions and Needs of People with Cancer, Their Family Members, and Caregivers. Support Care Cancer. 2025 Aug 8;33(9):770. doi: 10.1007/s00520-025-09838-3. PMID: 40781496.

Ellison LK, Ng C, Kewayosh A, Troke N, Elias B, Tjepkema M, Letendre A, Marrett LD, Sheppard AJ. Ancestry or identity? The importance of Indigenous engagement in articulating First Nations, Inuit and Métis peoples in the 2006 Canadian Census Health and Environmental Cohort (CanCHEC). Int J Circumpolar Health. 2025 Dec;84(1):2495378. doi: 10.1080/22423982.2025.2495378. Epub 2025 Apr 24. PMID: 40272120.

Hinton P, Rodriguez-Villamizar LA, Prince P, Prendergast T, Do MT, Demers PA, Peters CE, Zablotska LB, Villeneuve PJ. Protracted exposure to low-dose ionising radiation and cancer incidence among Canadian nuclear power plant workers. Occup Environ Med. 2025 Oct 17;82(8):370-379. doi: 10.1136/oemed-2025-110257. PMID: 40983508.

Kohan A, Metser U, Luke W, Rashid M, Langer DL, MacCrostie P, Green B, Mak V, Kulkarni GS, Finelli A, Shayegan B, Pautler SE, Klotz L, Hagerty M, Lavallée LT, Hildebrand C, Bauman G. A Prospective Provincial Registry of 18F-PSMA PET/CT for Recurrent Prostate Cancer: Results for 4,135 Men. J Nucl Med. 2025 Aug 1;66(8):1223-1231. doi: 10.2967/jnumed.125.269653. PMID: 40610233.

Lambert-Côté L, Turgeon A, Blackmore KM, Chang A, Antoniou AC, Bell KA, Broeders MJ, Brooks JD, Carver T, Chang SL, Chiquette J, Demers E, Easton DF, Eisen A, Eloy L, Evans DGR, Fienberg S, Joly Y, Kim RH, Knoppers BM, LabeauCaouette C, Lessard J, Lofters A, Nabi H, Paquette J-S, Pashayan N, Sheppard AJ, Stockley TL, Walker MJ, Chiarelli AM, Simard J, Dorval M. Psychological and emotional impacts of communicating breast cancer risk using multifactorial assessment with polygenic risk score: findings from PERSPECTIVE I&I. Genet Med. 2025 Aug;27(8):101453. doi: 10.1016/j.gim.2025.101453. Epub 2025 May 10. PMID: 40365755.

Levy BB, Goodman J, Gomes A, Martino R, Noel CW, Kamalraj P, Wright FC, Irish JC, Conn LG, Eskander A. Challenges and Opportunities for Speech-Language Pathology Services in Comprehensive Head and Neck Cancer Care: Insights From a Mixed Methods Study. Head Neck. 2025 Nov;47(11):3131-3140. doi: 10.1002/hed.28234. Epub 2025 Jul 3. PMID: 40611542.

Liszewski B, Hanna TP, Ishmail N, Malkoske K, D’Alimonte L, Pantarotto J, Gutierrez E, Kraus J, Ramprashad A, Berry K. Beyond the first course: Re-irradiation practices in Ontario—Insights from a provincial survey. Tech Innov Patient Support Radiat Oncol. 2025 Sep 4:100343. doi: 10.1016/j.tipsro.2025.100343.

Muñoz CE, Dai WF, Cheung WY, de Oliveira C, Pataky RE, Ding PQ, Tran DA, Aurangzeb Z, Nagamuthu C, Liu N, Lethbridge L, McClure C, Vriends K, Xiong H, Folkins C, Somayaji C, Peacock S, Alvi R, Turner D, O'Conaill C, McDonald T, Urquhart R, Kendell C, Dowden J, Strumpf E, Denburg A, Beca JM, Mercer RE, Tadrous M, Takhar P, Chan KKW; CanREValue Collaboration. Real-world comparative effectiveness and safety of Pertuzumab in patients with HER2+ metastatic breast cancer: A pan-Canadian population-based cohort study. Int J Cancer. 2025 Sep 1;157(5):927-940. doi: 10.1002/ijc.35448. Epub 2025 Apr 23. PMID: 40268528.

Omeranovic A, Lapointe J, Fortier P, Bergeron AS, Dorval M, Chiquette J, Boubaker A, Eloy L, Turgeon A, Lambert-Côté L, Joly Y, Brooks JD, Walker MJ, Stockley T, Pashayan N, Antoniou A, Easton D, Chiarelli AM, Knoppers B, Simard J, Nabi H. Primary care providers' experience and satisfaction with personalised breast cancer screening risk communication: a descriptive cross-sectional study. BMJ Open. 2025 May 2;15(5):e093936. doi: 10.1136/bmjopen-2024-093936. PMID: 40316347.

Perdrizet K, Le LW, Lau A, Tai X, Rabey MR, Law JH, Maziak D, Leighl N. Impact of the COVID-19 Pandemic on Diagnosis and Multidisciplinary Treatment of NSCLC in Ontario, Canada. JTO Clin Res Rep. 2025 Jun 19;6(9):100869. doi: 10.1016/j.jtocrr.2025.100869. PMID: 40832568.

Piedimonte S, McCurdy BR, Murphy J, Costescu D, Barg C, Li Y, Karapetyan T, Gao J, Kupets R. The Incidence of Vaginal Intraepithelial Neoplasia 2+ in Patients With Previous Hysterectomy Cervival Intraepithelial Neoplasia 3+ Between 2005-2015: A Population-Based Study. J Low Genit Tract Dis. 2025 Jul 1;29(3):239-242. doi: 10.1097/LGT.0000000000000894. PMID: 40576259.

Ssenyonga N, Stiller CA, Marcos-Gragera R, Kuehni CE, Saint-Jacques N, Bulliard JL, Redaniel MT, Nakata K, Schwartz S, De P, Ragusa R, Troussard X, Curado MP, Girardi F, Maynadié M, Valkov M, Guilloteau A, Lima C, Coleman MP, Allemani C; CONCORD Working Group. Conditional survival of children, adolescents and young adults (0-24 years) diagnosed with leukaemia during 2000-2014 world-wide: (CONCORD-3). Eur J Cancer. 2025 Jul 25;225:115445. doi: 10.1016/j.ejca.2025.115445. Epub 2025 May 23. PMID: 40578047.

Tai X, Muñoz CE, Arias J, Robinson AG, Kuruvilla MS, Brulé S, Chaudhry M, Gavura S, Habbous S, Somé N, Chan KK. Evaluation of interim modifications for extended dosing intervals of durvalumab for locally advanced unresectable stage III non-small cell lung cancer during the COVID-19 pandemic. Ann Cancer Epidemiol. 2025 May 30;9:3. doi: 10.21037/ace-24-16.

Wolfe DM, Hamel C, Berard J, Veroniki AA, Skidmore B, Kanji S, Rabheru K, McGee SF, Forbes L, de Lima Machado I, Liu M, Saunders D, Vandermeer L, Clemons M, Hutton B. Comparative Effectiveness of Interventions to Treat Cancer Treatment-Related Cognitive Impairment in Adult Cancer Survivors Following Systemic Therapy: A Systematic Review with Network Meta-Analyses. Cancers (Basel). 2025 Oct 26;17(21):3430. doi: 10.3390/cancers17213430. PMID: 41228226.

Yang J, Martin T, Mak V, Rashid M, Hunter A, Zhang L, Bartoszko J, Zuckerman J, Hallet J, Wright FC, Callum J. Evaluating variability in use of intravenous albumin in patients undergoing surgery for cancer. Can J Surg. 2025 Oct 17;68(5):E410-E421. doi: 10.1503/cjs.013823. PMID: 41107063.

Articles by external researchers utilizing Cancer Care Ontario data

Ajaj R, Gershon AS, Lau C, Gupta S, Baxter NN, Sutradhar R, Pole JD, Shaikh F, Nathan PC. Pulmonary toxicity in children, adolescents, and young adults with testicular germ cell tumors: A population-based retrospective matched cohort study. Int J Cancer. 2025 Nov 1;157(9):1841-1852. doi: 10.1002/ijc.70017. Epub 2025 Jun 24. PMID: 40553009.

Bateni SB, Law CHL, Nadler A, Shariff F, Chan WC, Raphael M, Myrehaug S, Coburn NG, Hallet J. Patient-Reported Symptom Burden Associated with Treatment Modality for Malignant Bowel Obstruction. Ann Surg. 2025 May 5. doi: 10.1097/SLA.0000000000006745. Epub ahead of print. PMID: 40323063.

Bondzi-Simpson A, Sutradhar R, Wright FC, Ribeiro T, Chan WC, Perera S, Covelli A, Lofters A, Snyder RA, Clarke CN, Coburn NG, Hallet J. Association of Traditional and new Surgical Wait Time Targets and Survival for Curative-intent Colorectal Cancer Surgery: A Population-based Cohort Study. Ann Surg. 2025 Oct 1;282(4):608-619. doi: 10.1097/SLA.0000000000006846. Epub 2025 Jul 23. PMID: 40698777.

Christensen RAG, Anderson GM, Kim SJ, Aminoleslami A, Brooks JD. Adherence to breast screening guidelines and breast cancer mortality: a population cohort study. Breast Cancer Res Treat. 2025 Aug;213(1):63-69. doi: 10.1007/s10549-025-07754-y. Epub 2025 Jul 3. PMID: 40608179.

Dossa F, Baxter NN, Sutradhar R, Little T, Velsher L, Lerner-Ellis J, Eisen A, Metcalfe K. Trends in the Utilization of BRCA1 and BRCA2 Testing After the Introduction of a Publicly Funded Genetic Testing Program. Curr Oncol. 2025 Aug 6;32(8):439. doi: 10.3390/curroncol32080439. PMID: 40862808.

Eng L, Faour E, Sutradhar R, Kaliwal Y, Niu Y, Liu N, Liu Y, Powis M, Liu G, Peppercorn JM, Krzyzanowska MK, Alibhai SMH. Impact of age and frailty on acute care use during immune checkpoint inhibitor treatment. J Natl Cancer Inst. 2025 Dec 26:djaf373. doi: 10.1093/jnci/djaf373. Epub ahead of print. PMID: 41452749.

Fatiregun O, Sutradhar R, Podolsky S, Eisen A, Paszat L, Rakovitch E. Appropriate Treatment for Stage 1 and 2 Her2-Positive and Triple-Negative Breast Cancer by Immigration Status in Ontario, Canada. Clin Breast Cancer. 2025 Jul 18:S1526-8209(25)00209-5. doi: 10.1016/j.clbc.2025.07.013. Epub ahead of print. PMID: 40819977.

Garg R, Dumont T, McCormack D, Tadrous M, Campbell T, Chan K, Gomes T. Trends in the Cost and Utilization of Publicly Reimbursed Cancer Medications Dispensed as Take-Home Treatments from 2017–2021. Curr Oncol. 2025 Apr 18;32(4):237. doi: 10.3390/curroncol32040237. PMID: 40277793.

Giblon R, Mahar A, Hallet J, Kelly C, Coburn N, Shooshtari S, Sutradhar R. Intellectual and developmental disabilities (IDD) and cancer symptom reporting: a matched retrospective cohort study. Support Care Cancer. 2025 Jun 12;33(7):571. doi: 10.1007/s00520-025-09620-5. PMID: 40506645.

Gong IY, Vijenthira A, Ante Z, Calzavara A, Hshieh TT, DuMontier C, Abel GA, Driver JA, Alibhai SMH, Prica A, Cheung MC, Mozessohn L. Association of Polypharmacy and Potentially Inappropriate Medications With Outcomes in Older Adults With DLBCL: A Population Study. J Natl Compr Canc Netw. 2025 Jun 27;23(8):e257029. doi: 10.6004/jnccn.2025.7029. PMID: 40578806.

Hanna NM, Shakeel S, Akhtar-Danesh GG, Finley C, Akhtar-Danesh N. The Impact of Social Determinants of Health on Treatment Received in Patients with Stage I Lung Cancer in Ontario: A Population-Based Analysis. Curr Oncol. 2025 Dec 18;32(12):713. doi: 10.3390/curroncol32120713. PMID: 41440241.

Hansford RL, Wilson B, Griffiths R, Mahar AL. Intellectual or developmental disabilities and curative female breast cancer treatment: A population-based retrospective cohort study. Breast. 2025 Aug;82:104509. doi: 10.1016/j.breast.2025.104509. Epub 2025 May 27. PMID: 40523325.

Iqbal J, Moineddin R, Quinn KL, Booth CM, Earle CC, Lheureux S, Grant R, Lau J, Le LW, Tanuseputro P, Downar J, Rodin G, Seow H, Tsai J, Fowler RA, Hannon B, Krzyzanowska MK, Zimmermann C. Novel Systemic Anticancer Treatments and Health Services Use at the End of Life Among Adults With Cancer. J Clin Oncol. 2025 Oct 20;43(30):3279-3291. doi: 10.1200/JCO-24-02816. Epub 2025 Jun 4. PMID: 40466035.

Lofters AK, Premranjith P, Gayowksy A, Khalil I, Covelli AM, Daniel JM. COVID-19 impacts on the breast cancer care pathway among systemically marginalized communities in Ontario. Cancer Causes Control. 2025 Dec;36(12):1927-1940. doi: 10.1007/s10552-025-02063-7. Epub 2025 Sep 24. PMID: 40987994.

Nathan PC, Lau C, Ng VL, Miserachs M, Teoh CW, Solomon M, Dipchand AI, Locke M, Gupta S. Outcomes after solid organ transplantation in survivors of childhood, adolescent and young adult cancer: A population-based study. J Natl Cancer Inst. 2025 Sep 1;117(9):1809-1816. doi: 10.1093/jnci/djaf106. Epub 2025 Apr 24. PMID: 40272994.

Ngo NNM, Brooks JD. Earlier screening, better outcomes? Revisiting breast cancer screening guidelines for women in their 40s. Can J Public Health. 2025 Oct 20. doi: 10.17269/s41997-025-01112-7. Epub ahead of print. PMID: 41116146.

Omar AT, Diestro JDB, Aghanya V, Dare AJ, Spears J, Gomez D. Cancer Health Disparities Affecting Glioblastoma Survival in Ontario, Canada: A Population-Based Study. Neurology. 2025 Jul 8;105(1):e213742. doi: 10.1212/WNL.0000000000213742. Epub 2025 Jun 9. PMID: 40489718.

Smith-Bindman R, Alber SA, Kwan ML, Pequeno P, Bolch WE, Bowles EJA, Greenlee RT, Stout NK, Weinmann S, Moy LM, Stewart C, Francisco M, Kofler C, Duncan JR, Ducore J, Mahendra M, Pole JD, Miglioretti DL. Medical Imaging and Pediatric and Adolescent Hematologic Cancer Risk. N Engl J Med. 2025 Oct 2;393(13):1269-1278. doi: 10.1056/NEJMoa2502098. Epub 2025 Sep 17. PMID: 40961449.

Villemure-Poliquin N, Fu R, Li Q, Ayoo K, Chan KKW, Karam I, Wright FC, Coburn NG, Hallet J, Eskander A. Patients With Head and Neck Cancer and High Health Care Costs: A Population-Based Study. JAMA Otolaryngol Head Neck Surg. 2025 Dec 1;151(12):1138-1147. doi: 10.1001/jamaoto.2025.1976. PMID: 40674044.