cobimetinib
Other Name: Cotellic™
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For treating a certain type of melanoma (skin cancer)
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Cobimetinib is usually used together with another medication called vemurafenib.
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Tell your health care team if you have or had significant medical condition(s) such as:
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heart, bleeding, muscle, liver or eye problems,
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diabetes, or
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any allergies.
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People with cancer have a higher risk of getting other cancers. Some cancer medications may increase these risks, especially if used for a long time. Discuss any concerns about this medication with your health care team.
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This drug contains a small amount of lactose. If you cannot tolerate lactose, talk to your health care team.
- The use of this medication in men or women may cause harm to the unborn baby if pregnancy occurs. Let your health care team know if you or your partner is pregnant, becomes pregnant during treatment, or if you are breastfeeding.
- If there is any chance that you or your partner may become pregnant, you and your partner together must:
- Use 2 effective forms of birth control at the same time while taking this drug. Keep using birth control for at least 3 months after your last dose unless your health care team told you differently. Talk to your health care team to figure out the best method(s) for you and/or your partner.
- Do not breastfeed while using this drug.
- This medication may affect fertility (ability to get pregnant)
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Cobimetinib is usually taken by mouth once daily for 21 days, followed by a 7 day break with no cobimetinib treatment (3 weeks on, 1 week off).
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During the 7 day break with no cobimetinib treatment, you should keep taking vemurafenib as directed by your health care team.
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Start your next cobimetinib treatment cycle after the 7 day break.
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Take the dose at about the same time each day.
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Swallow tablets whole with a glass of water, with or without food.
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If you miss a dose, take it if it is within 12 hours from the missed dose, otherwise skip and take your next dose as scheduled. Do not double the dose to make up for the forgotten one.
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If you vomit after taking cobimetinib, skip that dose and take your next dose as scheduled.
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This medication can interact with other medications and can result in the treatment not working as well or cause severe side effects.
- Make sure your health care team knows about all your medications (prescription, over-the-counter, herbals and supplements) especially antibiotics, antifungals, seizure medications and St. John’s Wort. Check with your health care team before starting or stopping any of them.
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Do not eat or drink grapefruit, starfruit, Seville oranges or their juices (or products that contain these) while taking this drug. They may increase the amount of drug in your blood and increase side effects.
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Cobimetinib can make you more sensitive to sunlight. Use lip balm and a broad-spectrum sunscreen with SPF 30 or higher and wear clothing and eyewear that protects you from the sun.
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Use caution when driving or operating dangerous machinery while you are taking cobimetinib as it can cause dizziness, make you feel tired or affect your vision.
- For mild aches and pain:
- You may take acetaminophen (Tylenol®) tablets. Ask your health care team about the right dose for you.
- Ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or aspirin (acetylsalicylic acid, ASA), including low dose aspirin for heart conditions, may increase your chance of bleeding.
- Talk to your health care team before you start or stop these medications.
- If you feel unwell, take your temperature before taking any of these medications. They may hide a fever.
- Talk to your health care team or go to the closest emergency room right away if you have a fever. See the Fever pamphlet for more information.
- Drinking alcohol and smoking during your treatment may increase some side effects and make your medication less effective. Speak to your health care team about smoking and drinking alcohol while on treatment.
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Keep this medication in the original packaging at room temperature in a dry place, away from heat and light. Keep out of sight and reach of children and pets.
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Do not throw out any unused medications at home. Bring them to your pharmacy to be thrown away safely.
You may not have all of the side effects below. You may have side effects that are not listed.
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Breakdown of muscle cells (rarely severe)
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Get emergency medical help right away | ||||
Abnormal liver lab tests (may be severe)
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Contact your health care team if no improvement or if severe | ||||
Salt imbalances It may cause muscle twitching, severe weakness or cramping, confusion and irregular heartbeat. |
Get emergency medical help right away | ||||
Diarrhea May happen days to weeks after you get your treatment. If you have diarrhea :
See the Diarrhea pamphlet for more information. |
Contact your health care team if no improvement or if severe |
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Skin sensitivity to sunlight Your skin may be more sensitive to the sun. You can have an itchy rash and other skin reactions when you are exposed to the sun.
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Contact your health care team if no improvement or if severe | ||||
Nausea and vomiting (generally mild) May occur in hours to days after your treatment. If you have nausea or vomiting:
Also see Nausea & Vomiting pamphlet for more information. |
Contact your healthcare team if nausea lasts more than 48 hours or vomiting lasts more than 24 hours |
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Fever and chills
While you are getting treatment:
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Contact your health care team if no improvement or if severe |
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High blood pressure
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Contact your health care team if no improvement or if severe | ||||
Rash Rash may be severe in some rare cases and cause your skin to blister or peel. If this happens, get emergency medical help right away. |
Contact your health care team if no improvement or if severe | ||||
Unusual bleeding or bruising
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Get emergency medical help right away | ||||
Low platelets in the blood
See the Low Platelet Count pamphlet for more information. See our Neutropenia (Low white blood cell count) pamphlet for more information. |
Get emergency medical help right away | ||||
Eye problems
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Contact your health care team as soon as possible | ||||
Heart problems You may have an irregular heartbeat, shortness of breath, chest pain, fainting spells or swelling in your legs, ankles and belly. |
Get emergency medical help right away |
Other rare, but serious side effects are possible.
If you experience ANY of the following, speak to your cancer health care provider or get emergency medical help right away:
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Heart is racing or fluttering, weakness, decreased ability to exercise, tiredness, dizziness, light-headedness, confusion, chest pain
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Difficulty breathing which may be accompanied by cough, fever, chills or coughing up blood
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New warts, skin sores or reddish bumps that bleed or does not heal or any unusual changes in your skin
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Swollen lips, face or tongue, chest and throat tightness
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Severe belly pain, bloating or feeling of fullness and severe constipation
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Lower back pain, swelling, peeing less than usual or unusual weight gain
Who do I contact if I have questions or need help?My cancer health care provider is: ______________________________________________ During the day I should contact:________________________________________________ Evenings, weekends and holidays:______________________________________________
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Other Notes:
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May 2021 Updated "What is this medication for" section
For more links on how to manage your symptoms go to www.cancercareontario.ca/symptoms.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.