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Fluoropyrimidine Treatment in Patients with Dihydropyrimidine Dehydrogenase (DPD) Deficiency: Guidance for Clinicians

Version: 1 Apr 2023
Type of Content: Guidelines & Advice, Clinical
Document Status: Current
Sarah Salama, Leta Forbes, Daniela Gallo-Hershberg

Guideline Objective

To provide clinicians with guidance on implementation of routine, pre-treatment DPYD testing and genotype-guided dosing for cancer patients with planned fluoropyrimidine treatment in Ontario.

Patient Population

Cancer patients who are candidates for systemic treatment with fluoropyrimidines (5-fluorouracil or capecitabine)

Intended Guideline Users

Health care providers involved in the care of cancer patients who have planned systemic treatment with fluoropyrimidines (medical oncologists, nurses, pharmacists)

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