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Recommendations for the Treatment of Patients with Clinical Stage III Non-Small Cell Lung Cancer: Endorsement of the 2019 National Institute for Health and Care Excellence Guidance and the 2018 Society for Immunotherapy of Cancer Guidance

Version: 4 ID: GL END 7-3 Apr 2020
Type of Content: Guidelines & Advice, Clinical
Document Status: Current
Authors:
A. Robinson, E.T. Vella, P.M. Ellis, R. Goffin, W. Hanna, D. Maziak, A. Swaminath, Y.C. Ung, Lung Cancer Disease Site Group

Guideline Objective

The goal of this guideline was to provide recommendations for the treatment of patients with clinical stage III non-small cell lung cancer.

Patient Population

Patients with Clinical Stage III Non-Small Cell Lung Cancer.

Intended Guideline Users

The intended users are oncologists and thoracic surgeons involved in the treatment of patients with stage III NSCLC.

Research Questions

  1. Should neoadjuvant chemoradiation plus surgery vs. neoadjuvant chemotherapy plus surgery be used in patients with potentially resectable stage III N2 NSCLC?
  2. Should neoadjuvant chemoradiation plus surgery vs. neoadjuvant chemoradiation and no surgery be used in patients with potentially resectable stage III N2 NSCLC?
  3. Should patients with unresectable clinical stage III NSCLC who have not progressed following completion of concurrent chemoradiation be considered for consolidation immunotherapy vs. concurrent chemoradiation alone?
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