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Systemic Therapy for Advanced Gastric Cancer

Version: 2 ID: 2-26 May 2014
Type of Content: Guidelines & Advice, Clinical
Document Status: In-Review
M. Mackenzie, K. Spithoff, D. Jonker , Gastrointestinal Cancer Disease Site Group

Patient Population

Adult patients with advanced (non-resectable; either locally advanced or metastatic) gastric cancer. These recommendations apply to patients with adenocarcinoma of the gastroesophageal junction but not to squamous cell carcinomas.

Intended Guideline Users

Clinicians and healthcare providers involved in the management or referral of adult patients with advanced gastric cancer.

Research Question(s)

What is the optimal chemotherapy regimen in advanced gastric cancer? Outcomes of interest are overall survival (OS), objective response rate (ORR; complete plus partial response), time-to-disease progression (TTP), adverse effects, and quality of life.

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