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The Role of Bisphosphonates in the Management of Skeletal Complications for Patients with Multiple Myeloma

ID: 6-4 Oct 2012
Type of Content: Guidelines & Advice, Clinical
Document Status: Education and Information
Hematology Disease Site Group

Patient Population

Adult patients with active plasma cell myeloma (symptomatic stage 1 or greater).

Research Question(s)

For patients with active multiple myeloma, is there evidence that the use of bisphosphonates:

  1. Improves survival?
  2. Improves quality of life?
  3. Reduces bone pain?
  4. Reduces or delays the development of skeletal complications? 
  5. For patients with multiple myeloma who receive treatment with a bisphosphonate:
  6. What is the association of bisphosphonates with osteonecrosis of the jaw (ONJ)? 
  7. How can this complication be prevented and managed?
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