Funded Biomarker Testing
48 items
1p/19q, CDKN2A testing should be performed on patients who test positive for an IDH1 mutation.
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: 1p/19q, CDKN2A
Testing Method:Single Nucleotide Polymorphism (SNP)
Testing Site: London Health Sciences Centre, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network
Evaluation of genomic biomarkers in cases of MDS, MPN, or MDS/MPN for diagnostic sub-classification, prognosis or therapeutic guidance.
Funded Biomarker Disease Site: Hematology
Biomarker: TBC
Testing Method:Panel
Testing Site: Children's Hospital of Eastern Ontario (CHEO), Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, University Health Network
For IDH Wild-Type patients diagnosed with Grade II and III tumours, sequencing should be performed.
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: +7/-10
Testing Method:Single Nucleotide Polymorphism (SNP)
Testing Site: London Health Sciences Centre, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network
For IDH wild-type patients diagnosed with Grade II and III tumours, sequencing should be performed.
Funded Biomarker Disease Site:
Biomarker: EGFR, IDH, TERT
Testing Method:Sequencing
Testing Site: London Health Sciences Centre, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network
H3-K27M testing should be performed on patients diagnosed with a glioma tumour in the midline location.
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: H3-K27M
Testing Method:Immunohistochemistry (IHC)
Testing Site: London Health Sciences Centre, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network
MGMT testing should be performed on all Grade IV patients > 55, all Grade III patients >55 and IDH wild-type Grade III patients ≤ 55.
Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: MGMT Methylation
Testing Method:Methylation
Testing Site: London Health Sciences Centre, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network
Newly diagnosed cases of cervical carcinoma where HPV cannot be determined from histology/p16 staining.
Funded Biomarker Disease Site: Cervix
Biomarker: HPV
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hamilton Health Sciences, Health Sciences North, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, University Health Network
Newly diagnosed cases of penile carcinoma where HPV cannot be determined from histology/p16 staining.
Funded Biomarker Disease Site: Penile
Biomarker: HPV
Testing Method:In Situ Hybridization (ISH)
Testing Site: Hamilton Health Sciences, Health Sciences North, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, University Health Network
Newly diagnosed cases of squamous cell carcinoma where HPV cannot be determined from histology/p16 staining.
Funded Biomarker Disease Site: Head and Neck
Biomarker: HPV
Testing Method:In Situ Hybridization (ISH)
Testing Site: Health Sciences North, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, Sunnybrook Health Sciences Centre, University Health Network
Reflex testing for all newly diagnosed paragangliomas (to inform need for germline testing)
Funded Biomarker Disease Site: Multiple Disease Sites
Biomarker: SDHB
Testing Method:Immunohistochemistry (IHC)
Testing Site: London Health Sciences Centre, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, University Health Network, William Osler Health System
Reflex testing for the diagnosis of serous tumours (epithelial ovarian, fallopian tube, peritoneal cancers) when needed to establish histologic subtype.
Funded Biomarker Disease Site: Ovary
Biomarker: p53, WT1
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hamilton Health Sciences, Health Sciences North, Kingston Health Sciences Centre, London Health Sciences Centre, Markham Stouffville Hospital (Oak Valley Health), Mount Sinai Hospital, North Bay Regional Health Centre, North York General Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, Unity Health - St. Michael's Hospital, University Health Network, William Osler Health System
Reflex testing on all metastatic thyroid cancer, including sporadic medullary and radio-iodine refractory well differentiated thyroid cancer.
Funded Biomarker Disease Site: Thyroid
Biomarker: BRAF, HRAS, NRAS, NTRK3, PPARG, RET, KRAS
Testing Method:Panel
Testing Site: Kingston Health Sciences Centre, London Health Sciences Centre, Mount Sinai Hospital, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System