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Funded Biomarker Testing

Find an overview of funded biomarker testing in Ontario. Information listed includes diagnostic, predictive and prognostic markers, as well as a summary of testing sites.

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Funded Biomarker Testing

7 items

Reflex testing on newly diagnosed adult cases of Ependymoma (infratentorial).

Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: chrom 1q gain, chrom 6q loss
Testing Method:Fluoroscence In Situ Hybridization (FISH), Single Nucleotide Polymorphism (SNP) Array
Testing Site: Hospital for Sick Children (SickKids)

Reflex testing on newly diagnosed adult cases of Ependymoma (infratentorial).

Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: EZHIP, H3 K27me3
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hospital for Sick Children (SickKids)

Reflex testing on newly diagnosed adult cases of medulloblastoma.

Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: CTNNB1, INI1/SMARCB1, FLNA, P53*, Nanostring/Methylation for subtyping
Testing Method:Immunohistochemistry (IHC), Nanostring
Testing Site: Hospital for Sick Children (SickKids)

Testing on all sinonasal carcinoma where HPV and EBV have been excluded

Funded Biomarker Disease Site: Head and Neck
Biomarker: SMARCA4, SMARCB1
Testing Method:Immunohistochemistry (IHC)
Testing Site: Hospital for Sick Children (SickKids), William Osler Health System

Testing on all sinonasal carcinoma where HPV and EBV have been excluded, and with retained/equivocal SMARC immunohistochemistry test results.

Funded Biomarker Disease Site: Head and Neck
Biomarker: DEK-AFF2, EWSR1-FLI, EGFR, IDH2, NUTM1, PAX3, PAX7
Testing Method:Sequencing
Testing Site: Hospital for Sick Children (SickKids), University Health Network

Testing on previously treated, unresectable locally advanced or metastatic cholangiocarcinoma (CCA) where FGFR2 directed therapy is being considered

Funded Biomarker Disease Site: Hepatobiliary
Biomarker: FGFR2
Testing Method:Sequencing
Testing Site: Hamilton Health Sciences, Hospital for Sick Children (SickKids), London Health Sciences Centre, Mount Sinai Hospital, St. Joseph's Healthcare Hamilton, Sunnybrook Health Sciences Centre, The Ottawa Hospital, Trillium Health Partners, University Health Network, William Osler Health System

TP53 testing should be performed on patients with an abnormal p53.

Funded Biomarker Disease Site: Central Nervous System (CNS)
Biomarker: TP53 SNV
Testing Method:Sequencing
Testing Site: Hospital for Sick Children (SickKids)