dexrazoxane
Other Name: Zinecard®
- Used to decrease the harmful effects on the heart caused by chemotherapy. It is not used as an anticancer drug by itself.
- Tell your doctor if you have/had significant medical condition(s), especially if you have / had kidney or liver disease, or have any allergies.
- People who have cancer are at a higher risk of developing other cancers or leukemias (usually some years later). Some cancer medications, such as dexrazoxane, may increase these risks especially if used for a prolonged period of time. You should discuss any concerns about this drug with your doctor.
- The use of this medication in men or women may cause harm to the unborn baby if pregnancy occurs. Let your health care team know if you or your partner is pregnant, becomes pregnant during treatment, or if you are breastfeeding
- ► Use 2 effective forms of birth control at the same time while taking this drug. Keep using birth control for at least 6 months after your last dose unless your health care team told you differently. Talk to your health care team to figure out the best method(s) for you and/or your partner.
- Do not breastfeed while using this drug.
- Effects on Fertility: Probable
- Effects on Fertility: Probable
-
This drug is given by injection into a vein.
-
This medication can interact with other medications and can result in the treatment not working as well or cause severe side effects.
-
Make sure your health care team knows about all your medications (prescription, over-the-counter, herbals and supplements). Check with your health care team before starting or stopping any of them.
-
For mild aches and pain:
- You may take acetaminophen (Tylenol®) tablets. Ask your health care team about the right dose for you.
- Ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or aspirin (acetylsalicylic acid, ASA), including low dose aspirin for heart conditions, may increase your chance of bleeding.
- Talk to your health care team before you start or stop these medications.
- If you feel unwell, take your temperature before taking any of these medications. They may hide a fever.
- Talk to your health care team or go to the closest emergency room right away if you have a fever. See the Fever pamphlet for more information.
The following side effects have been seen in people using dexrazoxane with other chemotherapy drugs, so some of these effects may also be related to chemotherapy.
The following side effects are common or severe. You may not have all of the side effects, while others may occur. Discuss with your doctor if you have any unusual or bothersome symptoms. Refer to the doxorubicin Medication Information Sheet for additional side effects when these drugs are used together.
|
|||||
|
Reactions at the injection site (redness, itchiness, bruising, mild rash or swelling)
|
- | ||||
|
|||||||
|
Unusual bleeding or bruising You may have black stools, cough up blood, blood in your urine, purple or red dots on your skin or bleeding that will not stop. Fever, chills, infection You have a fever if your temperature taken in your mouth (oral temperature) is:
While you are getting chemotherapy treatments:
If you have a fever, talk to your health care team or go to the closest emergency room. |
Get emergency medical help right away | ||||||
For more links on how to manage your symptoms go to https://www.cancercareontario.ca/en/symptom-management.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.