PACLitaxel
Other Name: Generic brand(s) available, Taxol®
mixed into larger bags of fluids
- For treating breast, lung, ovarian and other cancers
- Tell your doctor if you have or had significant medical condition(s), especially if you have or had:
- numbness or tingling in your hands or feet
- heart or liver problems
- low blood counts, or any allergies.
- People with cancer have a higher risk of getting other cancers or developing blood clots. Some cancer medications may increase these risks, especially if used for a long period of time. Discuss any concerns about this medication with your health care team.
- Paclitaxel contains a small amount of alcohol, and is given with allergy medications which may cause drowsiness. Avoid driving or operating machinery if you feel dizzy or drowsy after your treatment visit.
Remember to:
- Tell your health care team about all of the other medications you are taking.
- Keep taking other medications that have been prescribed for you, unless you have been told not to by your health care team.
You will have a blood test to check for hepatitis B before starting treatment. See the Hepatitis B and Cancer Medications pamphlet for more information.
- The use of this medication in men or women may cause harm to the unborn baby if pregnancy occurs. Let your health care team know if you or your partner is pregnant, becomes pregnant during treatment, or if you are breastfeeding
- If there is ANY chance that you or your partner may become pregnant, you and your partner together must:
- ►Use 2 effective forms of birth control at the same time while taking this drug. Do not take birth control pills if you have breast cancer. Keep using birth control until 6 months after the last dose. Discuss with your healthcare team.
- Do not breastfeed while taking this drug.
- This medication may affect fertility (ability to get pregnant)
This drug is given by injection into a vein.
- Dexamethasone and other medications may be given to help prevent an allergic reaction (either by injection or tablets).
- If you are using tablets, it is very important to take the dexamethasone exactly as directed by your doctor.
This medication can interact with other medications and can result in the treatment not working as well or cause severe side effects.
Make sure your health care team knows about all your medications (prescription, over-the-counter, herbals and supplements). Check with your health care team before starting or stopping any of them.
For mild aches and pain or fever:
- If you feel unwell, take your temperature before taking any medications for pain or fever. They may hide a fever.
- You may take acetaminophen (Tylenol®) tablets. Ask your health care team about the right dose for you.
- Ibuprofen (Advil®, Motrin®), naproxen (Aleve®) or aspirin (acetylsalicylic acid, ASA), including low dose aspirin for heart conditions, may increase your chance of bleeding. Talk to your health care team before you start or stop these medications.
- Talk to your health care team or go to the closest emergency room right away if you have a fever. See the Fever pamphlet for more information.
- If you feel unwell, take your temperature before taking any medications for pain or fever. They may hide a fever.
Drinking alcohol and smoking during your treatment may increase some side effects and make your medication less effective. Speak to your health care team about smoking and drinking alcohol while on treatment.
You may not have all of the side effects below. You may have side effects that are not listed.
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Hair thinning or loss
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Tingling, numb fingers and toes (may be severe)
| Contact your health care team if no improvement or if severe. | ||||
Mild joint, muscle pain or cramps (may be severe)
| Contact your health care team if no improvement or if severe. |
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Nausea and vomiting May occur in hours to days after your treatment. It is easier to prevent nausea than to treat it if it happens. To help prevent nausea:
If you have nausea or vomiting:
Also see Nausea & Vomiting pamphlet for more information. | Contact your healthcare team if nausea lasts more than 48 hours or vomiting lasts more than 24 hours. | ||||
Allergic reaction (may be severe)
| Get emergency medical help right away. | ||||
Unusual bleeding or bruising (may be severe) You may have black stools, cough up blood, blood in your urine, purple or red dots on your skin or bleeding that will not stop. Fever, chills, infection You have a fever if your temperature taken in your mouth (oral temperature) is:
While you are getting chemotherapy treatments:
| Get emergency medical help right away. | ||||
Diarrhea (may be severe) May happen days to weeks after you get your treatment. If you have diarrhea :
See the Diarrhea pamphlet for more information. | Contact your health care team if no improvement or if severe. |
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Abnormal liver lab tests (may be severe)
| Contact your health care team if no improvement or if severe. | ||||
Mild swelling in arms and legs; puffiness To help prevent swelling :
If you have swelling in your legs, keep your feet up when sitting.
| Contact your health care team if no improvement or if severe. | ||||
Mouth sores (may be severe) You may have round, painful, white or gray sores inside your mouth. They can occur on the tongue, lips, gums, or inside your cheeks. In more severe cases they may make it hard swallow, eat or to brush your teeth. They usually last 1 to 2 weeks.
See the Mouth Care pamphlet for more information.
| Contact your health care team as soon as possible. | ||||
Fatigue (tiredness)
See our Fatigue pamphlet for more information. | Contact your health care team if no improvement or if severe. | ||||
Reactions at the injection site (may be severe) Watch for redness, itchiness, bruising, mild rash and/or swelling. | Contact your health care team if no improvement or if severe. |
Other rare, but serious side effects are possible.
If you experience ANY of the following, speak to your cancer health care provider or get emergency medical help right away:
- irregular heartbeat, shortness of breath or chest pain
- sudden, severe pain in your belly or arm
- sudden confusion, trouble speaking or difficulty moving your arms or legs
- coughing up blood or trouble breathing
- pain and swelling of a vein in your arm or leg
- any changes in your vision
- severe bloating or feeling of fullness
- belly pain that extends to your back
- passing out or seizure
- severe rash that causes your skin to blister or peel
Who do I contact if I have questions or need help?My cancer health care provider is: ______________________________________________ During the day I should contact:________________________________________________ Evenings, weekends and holidays:_______________________________________
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Other Notes:
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June 2024 Revised/Updated information sheet
For more links on how to manage your symptoms go to www.cancercareontario.ca/symptoms.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.