vinCRIStine
Other Name: Oncovin®
- For treating leukemia, lymphoma, sarcoma, and less often in other cancers, usually in combination with other drugs.
- Tell your doctor and pharmacist if you have/had significant medical condition(s), especially if you have / had liver problems, nerve problems (numbness/tingling in your fingers and toes), or any allergies.
- People who have cancer or leukemia are at a higher risk of developing other cancers/leukemias (usually some years later) or blood clots. Some cancer medications may increase these risks, especially if used for a prolonged period of time. You should discuss any concerns with your doctor.
- Vincristine can harm the unborn baby and should not be used by pregnant women.
- If there is ANY chance that you or your partner may become pregnant, you and your partner together must: ►Use 2 effective forms of birth control at the same time while taking this drug. Keep using birth control until 6 months after the last dose (general recommendation). Discuss with your healthcare team.
- Tell your doctor right away if you or your partner becomes pregnant.
- Do not breastfeed while on vincristine treatment.
- Effects on Fertility: Probable
- Effects on Fertility: Probable
- This drug is only given by injection into a vein.
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Do not eat or drink grapefruit, starfruit, Seville oranges or their juices (or products that contain these) while on this treatment. They may increase side effects.
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This medication can interact with other medications and can result in the treatment not working as well or cause severe side effects.
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Make sure your health care team knows about all your medications (prescription, over-the-counter, herbals and supplements). Check with your health care team before starting or stopping any of them.
The following side effects are common or severe. You may not have all of the side effects. Other side effects may occur. If you have any unusual or bothersome symptoms, discuss with your doctor.
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Hair thinning or loss
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Constipation
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Contact your health care team if no improvement or if severe | ||||
Nausea and vomiting (usually mild)
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Contact your health care team if no improvement or if severe | ||||
Tingling, numb toes or fingers
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Contact your health care team if no improvement or if severe |
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Lung problems |
Get emergency medical help right away | ||||||
Rupture in stomach or intestine wall |
Get emergency medical help right away | ||||||
Hearing problems or loss |
Contact your health care team as soon as possible (office hours) | ||||||
Allergic reaction (fever, severe rash, itchiness, swollen face, lip or tongue, chest or throat tightness; may occur during or shortly after the drug is given) |
Get emergency medical help right away | ||||||
Unusual bleeding or bruising You may have black stools, cough up blood, blood in your urine, purple or red dots on your skin or bleeding that will not stop. Fever, chills, infection You have a fever if your temperature taken in your mouth (oral temperature) is:
While you are getting chemotherapy treatments:
If you have a fever, talk to your health care team or go to the closest emergency room. |
Get emergency medical help right away | ||||||
Pain, burning, redness, or swelling on skin where drug was injected
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Low measured salt levels in your blood which may lead to mild confusion or swelling |
Get emergency medical help right away | ||||||
Rapid killing of cancer cells when you start treatment may lead to build up of cell waste products
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Get emergency medical help right away |
For more links on how to manage your symptoms go to https://www.cancercareontario.ca/en/symptom-management.
The information set out in the medication information sheets, regimen information sheets, and symptom management information (for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.