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Primary Treatment for Locally Advanced Cervical Cancer: Concurrent Platinum-Based Chemotherapy and Radiation

ID: 4-5 Jun 2016
Type of Content: Guidelines & Advice, Clinical
Document Status: Current
H. Lukka, H. Hirte, A. Fyles, G. Thomas, M. Fung Kee Fung, M. Johnston , Gynecology Cancer Disease Site Group

Patient Population

Women with cervical cancer for whom primary treatment with radiotherapy is being considered:

  • Those with locally advanced cervical cancer
  • Those with bulky clinical stage IB (>4 cm) cervical cancer, who are treated with radiotherapy
  • Those with high-risk early-stage cervical cancer (node-positive or margin-positive), who will be treated with radiotherapy following hysterectomy

Research Question(s)

For women with cervical cancer in whom radiotherapy is considered appropriate, does the addition of concurrent platinum-based chemotherapy improve survival and quality of life with acceptable toxicity?

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pdf download Full Report (PDF) (947.65 KB)