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Alemtuzumab in Chronic Lymphocytic Leukemia

Version: 2 ID: 6-16 Version 2 Feb 2014
Type of Content: Guidelines & Advice, Clinical
Document Status: Education and Information
Authors:
G. Fraser, C.A. Smith, K. Imrie, R. Meyer , Hematology Disease Site Group

Patient Population

Adult patients with CLL.

Research Question(s)

  1. Is alemtuzumab a beneficial treatment option, with respect to outcomes such as survival, response rate, response duration, time-to-progression, and quality of life, for patients with Bcell chronic lymphocytic leukemia (CLL)?
  2. What toxicities are associated with the use of alemtuzumab?
  3. Which patients are more likely, or less likely, to benefit from treatment with alemtuzumab?