CISPVINO
CISplatin-Vinorelbine Treatment
This document provides general information about your cancer treatment. It does not replace the advice of your health care professional. Always discuss your therapy with your health care team.
- This treatment consists of CISplatin and Vinorelbine.
- Refer to the medication information sheet for each drug for more information
- CISplatin-Vinorelbine is a drug combination for treating non-small cell lung cancer.
- This chemotherapy regimen should not be used if you are pregnant or breast-feeding; if you or your partner may become pregnant (i.e. fertile/have not gone through menopause). Effective contraception with at least 2 methods is essential during treatment and for at least 6 months after stopping the treatment.
- Your oncologist will determine how many treatment cycles you need depending on how you tolerate and respond to the chemotherapy.
- Each cycle lasts 3 weeks (21 days). You will receive vinorelbine and cisplatin on the first day (Day 1) and vinorelbine* on Day 8 of each cycle through a vein in your arm (IV). Days 9 to 21 are rest days. {*Sometimes vinorelbine is also given on Days 15 and 22, thus changes each cycle to last 4 weeks (28 days).}
- You will have a blood test before each treatment to check if your blood counts are high enough for you to receive the next cycle of chemotherapy.
- Cisplatin can affect the function of your kidneys and can deplete some of the essential salts in your blood (such as magnesium). In order to preventing this, extra intravenous fluid will be given to you before and after each cisplatin infusion. Sometimes, magnesium might be added in the extra fluid or your doctor might prescribe an oral magnesium supplement for you to take at home for a few days after the treatment. it is important that you drink plenty of fluids (at least 8 glasses per day) during the day and empty your bladder (pass urine) frequently.
- Using other medications can affect the levels of chemotherapy drug in your blood (lowering level of drug making chemotherapy less effective, or increasing the level of drug causing more side effects.) Make sure your doctor and pharmacist have a complete list of all medicine and supplements (including over the counter ones and herbal products) that you are taking. Do not start or stop taking any medicine/supplements without first checking with your doctor and pharmacist.
- Rarely, treatment with this chemotherapy regimen may increase your chance of bleeding. Because of this, you should avoid using blood thinners, or drugs that also affect bleeding such as aspirin and nonsteroidal anti-inflammatory drugs such as ibuprofen (Advil®, Motrin ®). For headache, fever, or occasional aches and pains, use acetaminophen (Tylenol®) instead. If you are taking aspirin regularly for other medical problems, it is important that you do not stop taking it before you have discussed this with your doctor.
- Your oncologist or nurse will also assess your veins prior to starting chemotherapy. They may recommend that a tube is put in your vein to make sure that chemotherapy can be given to you safely.
The table below lists other common or important side effects with this treatment. You may not have all of the side effects. Other side effects may occur. If you have any unusual or bothersome symptoms, discuss with your doctor.
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Abnormal liver function tests (yellowing of skin and whites of eyes)
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Get emergency medical help right away | ||||||
Hair thinning or loss
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Contact your health care team if no improvement or if severe | ||||||
Poor Appetite; Don't feel like eating
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Contact your health care team if no improvement or if severe | ||||||
Constipation
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Contact your health care team if no improvement or if severe | ||||||
Diarrhea
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Contact your health care team if no improvement or if severe | ||||||
Hearing Loss, ringing in ears, and loss of balance
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Contact your health care team as soon as possible (office hours) | ||||||
Signs of infection, for example, fever, chills, cough, sore throat
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Get emergency medical help right away | ||||||
Nausea and vomiting
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Contact your health care team if no improvement or if severe | ||||||
Kidney failure, trouble urinating
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Get emergency medical help right away | ||||||
Numbness, tingling and burning sensation in hands and feet
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Contact your health care team if no improvement or if severe | ||||||
Pale skin, weakness, breathlessness, anemic
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Contact your health care team if no improvement or if severe |
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Low salts in your blood (magnesium, potassium, sodium, calcium & phosphate)
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Get emergency medical help right away | ||||||
Pain and redness at injection site
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Get emergency medical help right away |
For more links on how to manage your symptoms go to https://www.cancercareontario.ca/en/symptom-management.
The information set out in the medication information sheets, regimen information sheets, and symptom management information(for patients) contained in the Drug Formulary (the "Formulary") is intended to be used by health professionals and patients for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or side effects of a certain drug, nor should it be used to indicate that use of a particular drug is safe, appropriate or effective for a given condition.
A patient should always consult a healthcare provider if he/she has any questions regarding the information set out in the Formulary. The information in the Formulary is not intended to act as or replace medical advice and should not be relied upon in any such regard. All uses of the Formulary are subject to clinical judgment and actual prescribing patterns may not follow the information provided in the Formulary.