Evidence from Primary Studies and Systematic Reviews and Recommendations from Clinical Practice Guidelines July to December 2018

Guideline Objective

As part of a regular monitoring program recommended by the PEBC, a systematic review of recent evidence on the use of PET in patients with cancer, sarcoidosis, or epilepsy is conducted every six months. This report is intended to be a high-level, brief summary of the identified evidence, and not a detailed evaluation of its quality and relevance.

Patient Population

Adult and pediatric patients with suspected or diagnosed cancer(s), sarcoidosis, or epilepsy (The cancer is not limited to those cancers with approved or Ontario Health Insurance (OHIP) insured services).

Intended Guideline Users

Ontario PET Steering Committee

Research Questions

What is the role of positron emission tomography (PET) in the clinical management of patients with cancer sarcoidosis or epilepsy with respect to: Diagnosis and staging
Assessment of treatment response. Detection and restaging of recurrence. Evaluation of metastasis.

Outcomes of interest are survival, quality of life, prognostic indicators, time until recurrence, safety outcomes (e.g., avoidance of unnecessary surgery), and change in clinical management.