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Imatinib Mesylate (Gleevec™) for the Treatment of Adult Patients with Unresectable or Metastatic Gastrointestinal Stromal Tumours

Version: 3 ID: 11-7 May 2015
Type of Content: Guidelines & Advice, Clinical
Document Status: Archived
Authors:
S. Verma, J. Younus, D. Stys-Norman, A.E. Haynes, M. Blackstein , Sarcoma Disease Site Group

Patient Population

Adult patients with unresectable or metastatic GIST expressing KIT (CD117+).

Research Question(s)

Does treatment with imatinib mesylate (Gleevec™) have palliative benefit, in terms of tumour response, disease progression, survival or quality of life, for patients with unresectable or metastatic gastrointestinal stromal tumours (GIST) expressing the KIT tyrosine kinase receptor (identified by CD117 immunohistochemical staining)?

pdf download Full Report (PDF) (663.14 KB)